The star, who has been associated with PETA since 2002, appears in the campaign wearing an outift resembling snakeskin while posing in a pool of blood.
The 35-year-old said in a statement: "Wearing shoes, clothes and other accessories made out of exotic skin is about as cold-blooded as it gets."
Promoting the use of artificial materials in the fashion industry, Tandon commented: "These days, there's a wild kingdom of fake snake, mock crocodiles and python leather that pay tribute to the beauty of these animals without making them fashion victims."
The actress returns to the big screen later this year with Aap Ke Liye Hum.
