Aniston took Norman to a specialist canine therapist after the dog disappeared for a night and started acting unusually upon his return, claims Now magazine.
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A source said: "Jen became seriously worried about Norman's mental health after his disappearance. He came back dazed and lacklustre and often didn't seem to recognise her. She's concerned this could be it for him and she's devastated.
"The dog therapist said Norman was depressed and that's what was causing him to act oddly."
The therapist is said to have prescribed the 15-year-old pet with medication, but Aniston is intent on nursing him back to full health on her own.
The source added: "She's hoping to coax him out of it herself. People may laugh at her, but Norman really is her best friend. She can't bear to see him like this, but he's very old and she's starting to accept he might be on his last legs."
It was reported in 2008 that Aniston spent $250 (£159) on massage, acupuncture and Reiki sessions for Norman.
